To investigate the effects of Xiaoliu decoction combined with intraperitoneal hyperthermic perfusion chemotherapy on postoperative quality of life and serum vascular endothelial growth factor (VGEF) protein expression in patients with colorectal cancer, and to explore its mechanism of preventing or inhibiting postoperative recurrence and metastasis of colorectal cancer.Methods:A total of 82 patients underwent surgical treatment of colorectal cancer in our hospital from July 2011 to October 2013 were selected and randomly divided into control group and observation group according to the computer generated digital table, with 41 cases in each groups.The control group was treated with intraperitoneal hyperthermic perfusion chemotherapy, and after the patient with defecation, the observation group on the basis of the control group received Xiaoliu decoction treatment.The clinical efficacy, postoperative quality of life and the expression of VEGF and VEGF protein were compared between the 2 groups before and after treatment.Results:There was no significant difference in clinical efficacy between the 2 groups after treatment (P>0.05), and the recurrence and metastasis rate of the observation group was significantly lower than those of the control group within 3 years (P<0.05).After treatment, the functional scores of the 2 groups significantly increased, and the observation group was significantly higher than the control group (P<0.01); symptomatic scores significantly decreased, and the observation group was significantly lower than the control group (P<0.01); after treatment, the expression of VEGF and VEGF protein in the 2 groups were significantly lower (P<0.01), and the observation group was significantly lower than the control group (P<0.01).Conclusion:Xiaoliu decoction combined with intraperitoneal hyperthermic perfusion chemotherapy can effectively down-regulate the expression of VEGF and VEGF protein, reduce the recurrence and metastasis rate of colorectal cancer patients, and improve the quality of life.