Damp-heat is a common clinical basic syndrome.We selected some guide books closely related to clinical,teaching and scientific research,such as Internal Medicine of Traditional Chinese Medicine,Internal Medicine of Integrated Traditional Chinese and Western Medicine and Guiding Principles for Clinical Research of New Chinese Materia Medica (Trial).By analyzing the diseases and damp-heat syndromes that were listed in the books,we extracted the syndromes (sub-syndromes) associated with damp-heat syndromes and revealed the distribution characteristics of the disease,and summarized the damp-heat related syndromes.Damp-heat syndrome was found to be closely related to many major or chronic diseases such as metabolic diseases,chronic kidney disease,liver and gallbladder disease,spleen and stomach disease.However,the emphasis and research depth of damp-heat in major chronic diseases need to be improved,and the related syndromes of damp-heat are complex and need to be standardized.Therefore,it is primary to clarify the major chronic diseases related to damp-heat syndrome and establish standardized dialectical criteria.