To investigate the medication rules of draining water and dissolving stasis therapy in treating the damp-heat and blood stasis obstruction type urolithiasis, which could be the guidance for treating the urinary calculus on TCM.Methods:A total of 100 medical records and 324 prescriptions in our hospital during April 2015 to April 2016 were collected and analyzed.The frequencies and rates were collected and analyzed by the hierarchical cluster for studying the medication rules.Results:The frequency of 9 drugs was over 50.00%, and 13 drugs less than 25.00%, as well as 8 drugs between 25.00% and 50.00%.Then those 28 drugs were classified into 4 clusters.Conclusion:Focusing on the medicines of bladder meridian, draining water and dissolving stasis therapy was used to treat the urolithiasis on the pathogenesis of damp-heat and blood stasis obstruction type on the lower Jiao, which was concentrated on the channel tropism and adjusted measures to local conditions with Lingnan genuine medicinal materials.