To assess the effect of muscle-bone strengthening exercise for elderly primary osteoporosis by using meta-analysis.Methods:We searched CNKI,WanFang Data,Web of Science,The Cochrane Library,EMbase,PubMed,VIP and CBM,irrespective of language restrictions.The samples included randomized controlled trials(RCTs)regarding muscle-bone strengthening exercise for elderly osteoporosis.The quality was evaluated and studied by Cochrane handbook 5.1.0 and analyzed by RevMan 5.3 and Stata 11.0 software.Results:3 RCTs involving 185 subjects were included.Meta-analysis showed that muscle-bone strengthening exercise was statistically significant in improvement on bone mineral density(BMD)and femur neck BMD(FMBMD)(MD=0.54，95% CI [0.24，0.83],P=0.0004,MD=0.11，95% CI [0.07,0.15],P<0.00001).Additionally,muscle-bone strengthening exercise was statistically significant in relieving bone pain(MD=-0.82,95%CI [-1.09,-0.55],P<0.00001,MD=-1.65,95%CI[-1.99,-1.31],P<0.00001).However,problem on the data biochemical criterion of bone metabolism was doubted.Thus,data was not analyzed.Conclusion:Muscle-bone strengthening exercise has some effects on prevention and treatment of elderly primary osteoporosis.But we must be careful to that result due to few studies included and poor quality.