To explore the correlation between traditional Chinese medicine (TCM) syndrome type and skin lesions site as well as the severity score of melasma.Methods:A total of 246 patients with melasma treated at Dongfang Hospital of Beijing University of Chinese Medicine from January 2016 to December 2017 were selected to analyze the correlation between TCM syndrome type and skin lesions site as well as the severity score of melasma.Results:Between the melasma patients with different TCM constitution types，the total MASI score segmentation was significantly different.Yang deficiency accounted for the largest proportion in 0-10 points.Constitution of qi stasis accounted for the largest proportion in 10-20 points.Blood stasis constitution accounted for the largest proportion in 20-30 and 30-40 points.There was no significant difference in MASI scores of forehead and chin among different types of constitution，while there were significant differences in left zygomatic and right zygomatic scores.There were correlated relationship between the total MASI scores and MASI scores in different parts of different types of constitutions.MASI scores of patients of yang deficiency constitution，yin deficiency constitution，phlegm-dampness constitution and harmonious constitution had the highest correlation with MASI scores of right zygomatic.The MASI scores of blood stasis constitutions，qi stagnation constitution，damp-heat constitution and qi deficiency constitution had the highest correlation with MASI score of left zygomatic.There was no evidence of total MASI score associating with MASI scores in maxillary and chin among patients with melasma.Conclusion:There is a certain statistical correlation between the TCM constitution of melasma patients and skin lesions site as well as the severity score.A large sample studies and more advanced technology are still needed to test and verify the effects of different types of constitutions on the physiological characteristics of melasma.