To objectively evaluate the clinical curative effect through clinical research compound Xiangbai granules in the treatment of head seborrheic dermatitis，and to establish the standard of the external treatment of head seborrheic dermatitis research specification.Methods:A total of 80 cases of head seborrheic dermatitis patients were randomly divided into two groups，treatment group (40 cases) and control group (40 cases).The patients were treated with compound Xiangbai granules in the treatment group and 2% Ketoconazole Lotion in the control group.The symptom score and clinical effects of treatment were evaluated before the treatment and after 4 weeks.Results:The symptom scores of skin lesion area，erythema，scale，seborrhea and pruritus were markedly improved than pre-treatment in the both groups (all P<0.05).After treatment of 4 weeks，treatment group (PPS) has 40 cases，and total effective rate was 90%.Control group had 38 cases，and total effective rate was 65.8%.The treatment group was markedly higher than the control group (P<0.05).Conclusion:Compound Xiangbai granules is more effective in the treatment of head seborrheic dermatitis than that of 2% Ketoconazole Lotion，with high safety.Therefore，Compound Xiangbai granules is worthy of clinical use.