The pathogenesis of headache is complex，and liver is particularly closely related to the headache caused by internal damage.Jueyin liver meridian of foot and brain are closely linked in the meridian circulation.The wind characteristics of liver easily invade brain and cause headache.The liver dysfunction and liver-qi's upward invasion of brain disturbe the deity of the brain and cause headaches.The lack of blood store in liver can cause brain malnutrition and headache.Regulate liver to treat headache include the following aspects: 1）Soothing the liver and regulating qi method; 2）Dispersing the depressed liver-energy and dredging collateral method; 3）Dispersing stagnated liver qi for promoting bile flow method; 4）Removing heat from the liver method; 5）Soothing liver to subdue yang method； 6）Settling liver and extinguishing wind method; 7）Warming liver and reducing the reverse method; 8）Nourishing the liver blood method; 9）Nourishing kidney and liver method.