To observe the clinical efficacy of Jianpi Gushen Huayu Decoction combined with alprostadil in the treatment of diabetic nephropathy.Methods:A total of 100 patients with diabetic nephropathy in clinical period in Hospital of Integrated Traditional Chinese and Western Medicine from January 2016 to January 2017 were randomly selected for clinical study.The patients were divided into the observation group and the control group by random number method,with 50 cases in each group.The control group received routine treatment and was treated with alprostadil.The observation group was given the Jianpi Gushen Huayu Decoction on the basis of the same treatment of the control group.The Traditional Chinese Medicine (TCM) symptom score,clinical efficacy,renal function and blood glucose changes of the two groups were observed.Results:Scores of TCM symptoms in the two groups of patients before treatment had no significant difference,and were decreased after treatment,but scores of the observation group were lower than those of the control group; the total effective rate of observation group was 96%,which was significantly higher than that of 80% of the control group; there were no significant differences of concentrations of 24 hPRO,mAlb,Scr,BUN,GFR in two groups of patients before treatment,which were decreased after treatment.Concentrations of 24 hPRO,mAlb,Scr,BUN of the observation group were lower than those of the control group,while concentrations of GFR was higher than that of the control group; the two groups of patients were improved after treatment compared with before treatment,but there were no significant differences between the groups.Conclusion:The combination of Jianpi Gushen Huayu Decoction and alprostadil has good curative effect on diabetic nephropathy,and can improve the clinical symptoms and renal function,and the clinical efficacy.