To investigate the clinical effects and mechanism of Bushen Jianpi Tongluo Fang in the treatment of senile osteoporosis.Methods:A total of 80 patients with osteoporosis admitted in our hospital from April 2016 to February 2017 were selected and randomly divided into observation group and control group, with 40 cases in each group.The control group:oral calcium 1 capsule/time, 1 time/day; intravenous infusion of Yunke 1 time/day; the observation group was received Bushen Jianpi Tongluo Decoction based on the control group, 1 time in the morning and evening.10 days as a course of treatment, and 3 courses were observed.VAS pain score scale was used to assess the degree of pain before and after treatment.Bone mineral density was measured before and after treatment.Automatic biochemical analyzer was used to detect serum calcium, serum phosphorus, serum alkaline phosphatase; Enzyme-linked immunosorbent assay (ELISA) was applied to detect concentration changes of peripheral blood macrophage colony-stimulating factor (M-CSF) in two groups before and after treatment.Results:1) After treatment, the VAS pain scores of the two groups were decreased (P<0.05), and the observation group was better than the control group (P<0.05).The total effective rate of the observation group (90%) was better than that of the control group (72.50%) (P<0.05).2) Only calcium increased of two group after treatment (P<0.05), and the observation group was better than the control group (P<0.05).The serum phosphorus, serum alkaline phosphatase within and between groups were not significantly different (P>0.05).3) M-CSF in both groups decreased after treatment (P<0.05), and the observation group was better than the control group (P<0.05).Conclusion:The clinical symptoms of Bushen Jianpi Tongluo Decoction can effectively improve senile osteoporosis, and the mechanism may be associated with reduced serum calcium and the increase of M-CSF.