To investigate the effect of traditional Chinese medicine Qingjin Huatan decoction on TCMSS score and inflammatory factors in patients with severe pneumonia (type of phlegm-heat obstructing lungs). Methods:The clinical data of 75 cases of severe pneumonia diagnosed in our department from January 2015 to July 2016 were retrospectively analyzed. They were divided into groups according to different treatment methods. The control group (38 cases) received routine treatment, while the treatment group (37 cases) was given traditional Chinese medicine Qingjin Huatan Decoction on the basis of routine treatment. TCM syndrome scores (TCMSS), inflammatory factors and pulmonary function indexes between the two groups before and after treatment were observed and compared. Results:After treatment, the scores of TCM syndrome in two groups were significantly different from those before treatment (P<0.05), and the scores of TCM syndrome in treatment group were significantly lower than those in control group (P<0.05); After treatment, the inflammatory factors in the two groups were different from those before treatment (P<0.05), and the inflammatory factors in the treatment group were significantly better than those in the control group (P<0.05); The pulmonary function indexes of the two groups was significantly different from those before treatment (P<0.05), and the pulmonary function indexes of the treatment group was significantly better than those of the control group (P<0.05). Conclusion:Traditional Chinese medicine Qingjin Huatan Decoction can effectively reduce the TCM syndrome scores of patients with severe pneumonia (type of phlegm-heat obstructing lungs), reduce inflammatory mediators and cell levels, and optimize the lung function, which is recommended to use.