To observe the curative effects of self-made traditional Chinese medicine prescription combined with Metformin in the treatment of patients with type 2 diabetic nephropathy of yin deficiency of liver and kidney.Methods:A total of 146 patients with Type 2 diabetes nephropathy with yin deficiency of liver and kidney syndrome admitted to our hospital from December 2015 to May 2017 were randomly divided into observation group(self-made traditional Chinese medicine and western medicine)and control group(Western medicine treatment)according to random number table by the prospective randomized controlled trial,with 73 cases in each group.The levels of fasting blood glucose(FBG),urinary albumin excretion rate(HbAlc),serum creatinine(Scr),superoxide dismutase(SOD),dialdehyde(MDA)expression of 2 groups were compared after 3 courses of treatment.Results:The expression of FBG and HbAlc were decreased in both groups after treatment(P<0.05).The expression levels of FBG and HbAlc in the observation group were lower than that of the control group(P<0.05).The levels of UAER and Scr in both groups were decreased(P<0.05),while those in the observation group were lower than that of the control group after treatment(P<0.05).MDA expression decreased and SOD expression increased in the 2 groups,and the MDA level in the observation group was lower than that of the control group after treatment(P<0.05).Conclusion:Based on Western hypoglycemic regimen,blood glucose level,urinary protein excretion and renal pathological damage can be reduced by adding self-made Chinese herbal decoction.In addition,it can delay the development of diabetic nephropathy in type 2 diabetic patients.Its intervention may be related to the improvement of the imbalance of oxidative stress in vivo.