To explore the clinical effect of Bailing Capsules combined with Salvianolate in the treatment of diabetic nephropathy and the influence on endothelial function，renal function，oxidative stress and the index of renal vascular fibrosis.Methods:A total of 138 cases with diabetic nephropathy in Chongqing's Seventh People's Hospital from March 2016 to March 2018 were divided into the control group and the observation group according to random number table method，with 69 cases in each group.The control group was given Salvianolate combined with basic treatment; the observation group was given Bailing Capsules based on the treatment of control group.The clinical effect，renal function (BUN，Scr，24 h Upro，24 h UAER)，immune function (T cells，B cells，NK cells)，vascular endothelial function (MDA，SOD，GSH-Px)，renal vascular fibrosis (TGF-β1，MCP-1，CTGF) were observed in the two groups.Results:The level of BUN，Scr，24 h Upro，24 h UAER，SOD，GSH-Px after treatment were decreased than before treatment of two groups，and MDA was increased than before treatment.The above index of the observation group changed more obviously，and the differences were statistically significant (P<0.05).The CD3+CD8+T cell，CD3-CD16+CD56+NK cell increased obviously of the observation group after treatment，and the CD3-CD19+ B cell，CD3+CD4+ T cell，TGF-β1，MCP-1，CTGF decreased significantly in the observation group after treatment.The total effective rate of the observation group (91.30%) was higher than that of the control group (73.91%)，and the difference was statistically significant (P<0.05).Conclusion:Bailing Capsules combined with Salvianolate in the treatment of diabetic nephropathy can improve the renal function，regulate immune function，improve endothelial function，and inhibit the renal vascular fibrosis.