To observe the effects of Shennao Fuyuan Decoction on the influence and mechanism of nerve cell in rat hippocampus of Alzheimer's disease.Methods:A total of 120 healthy male SD rats were randomly divided into sham operation group(intracerebroventricular injection of 3 μL distilled water,),model group(intracerebroventricular injection of 3 μL Aβ25-35+distilled water administered intragastrically),Shennao Fuyuan Decoction group(intracerebroventricular injection of 3 μL Aβ25-35+Shennao Fuyuan Decoction administered intragastrically)and the control group(intracerebroventricular injection of 3 μL Aβ25-35+donepezil hydrochloride administered intragastrically).All the groups were administered intragastrically once and killed in 7,14,21 days.The changes of HE staining,tunnel staining and the levels of bFGF and BDNF protein were observed.Results:Compared with the model group,the degree of necrosis in the Chinese medicine group was mild,and the apoptosis in the traditional Chinese medicine group(14th day)was lower than that of the model group(P<0.01).Compared with the model group,the expression of bFGF and BDNF increased(P<0.05 or P<0.01)in the Chinese medicine group(7th day).Conclusion:Shennao Fuyuan Decoction is effective on the repairing nerve of rat hippocampus of AD disease,and plays a role in later period.Its mechanism is related to promoting the expression of BDNF and bFGF in hippocampus.