To investigate the clinical curative effects of back-shu and front-mu matching acupoints combined rehabilitation training on nonspecific low back pain, and to analyze part of mechanism of action.Methods:A total of 100 nonspecific low back pain patients in our hospital during March 2013 to April 2016 included into the study, were randomly divided into the control group and the observation group, with 50 cases in each group.50 cases of healthy examined people in the corresponding period were selected as healthy controls.The two groups of nonspecific low back pain accepted core muscle training.The observation group had back-shu and front-mu matching acupoints method.Both of the two groups had electric acupuncture apparatus, retained needle under the condition of dilatational wave for 30 min.McGILL grade, JOA lumbago disease curative effect, Oswestry disability index scores, waist abdominal muscle isometric contraction value of two groups were measured before and after treatment with.Meanwhile, peripheral blood beta-endorphin (β-EP) concentration changes of three groups were detected.Results:1) McGILL grade, JOA lumbago disease curative effect, Oswestry disability index scores were improved obviously after treatment in the two groups when compared with before the treatment (P<0.05).The improvement trend of the observation group was more significant compared with the control group after treatment (P<0.05).2) Lumbar abdominal muscle isometric contraction value in the two groups was significantly higher after treatment than before treatment (P<0.05), and the numerical of the observation group was significantly better than that of control group after treatment (P<0.05).3) β-EP concentrations of the two groups of patients with nonspecific low back pain were significantly higher than that of healthy controls before treatment, and the β-EP concentrations of the two groups down-regulated to a certain extent after intervention.The decreased of the observe group were more significantly compared with the control group after treatment (P<0.05).Conclusion:Back-shu and front-mu matching acupoints combined rehabilitation training can obviously alleviate the clinical discomfort of nonspecific low back pain, and its mechanism may be related to down-regulation of β-EP concentration of the body.