Antiviral drugs (western medicine) have advantages of etiological treatment, and traditional Chinese medicine have advantages of anti hepatic fibrosis. The combination of Chinese and western medicine can improve the reversal rate of hepatitis B cirrhosis. What is the key mechanism to improve the efficacy of integrative medicine? What are characteristics of target population for effective response? Starting from these questions, based on features of intrahepatic immune microenvironment, we made hypothesis that “regulating liver fibrosis immune microenvironment and restoring immune killing function of NK cells to activated HSC are main mechanisms of FZHY combined with ETV to effectively reverse HBV advanced liver fibrosis”. Firstly, we will utilize biochemical samples from two cohort of HBV cirrhosis established by national key grant, and analyze the characteristics of target population with hepatic immune microenvironment and TCM pattern. Then curative effect will be compared before and after treatment, and between two groups, to understand the main action mechanisms of combined therapy. The cirrhosis animal models with HBV will be established, treated with ETV and FZHY, intrahepatic cells and their relationship were assayed to investigate the regulation of integrative medicine on liver immunological disorder. Lastly, cirrhosis mice and human liver cells will be isolated, and then treated with FZHY, to study the FZHY effect on retinoid metabolism and liver immune cells interaction. These work will find the effective target population characteristics and the main therapeutic mechanism of TCM, promote development of precision medicine and basic research in the field of liver disease with integrative medicine.