To assess the efficacy and safety of Buyang Huanwu Decoction in treating hyperlipidemia.Methods:RCTs were collected by computer,using Revman5.3 software,from databases including the Cochrane library,PubMed,Embase,CNKI,CBM,VIP and Wanfang database.Results:A total of 6 RCTs were included,with 626 subjects in total.The total effect of lipid of Buyang Huanwu Decoction of the treatment group was higher than that of control group(RR=1.30,95%CI ［1.15,1.48］,P=0.001).The total cholesterol(TC)level of Buyang Huanwu Decoction was lower after treatment(WMD=-0.38,95%CI ［-0.68，-0.08］,P=0.01).The triglyceride(TG)level of Buyang Huanwu Decoction was indiscriminate with the control group after treatment(WMD=-0.16,95%CI ［-0.44,0.12］,P=0.28).The HDL-C level of Buyang Huanwu Decoction was indiscriminate with the control group after treatment(WMD=0.05,95%CI ［-0.11,0.21］,P=0.55).The level of low-density lipoprotein(LDL)was similar to that of the control group after treatment(WMD=0.09,95% CI［-0.64,0.82］,P=0.80).Compared with statins,the LDL-C level of Buyang Huanwu Decoction was lower(WMD=-0.48,95%CI ［-0.67，-0.29］,P=0<0.00001).There were no relevant reports about the incidence of adverse reactions.Conclusion:Buyang Huanwu Decoction may effectively improve hyperlipidemia,including TC,TG,HDL-C and LDL-C,and especially in TC.Buyang Huanwu Decoction is more effective in the improvement of TC and LDL-C than others.It is recommended that this treatment of hyperlipidemia should be used in clinical and to add more high quality relevant studies.