“Nexus Liver” is an innovative theory raised by Pro. Guo Jiao，who analyzed classic of traditional Chinese medicine in metabolite selected by her team's and combined her clinical researches in the past 30 years. This theory breaks the limits of therapies for metabolic diseases，and it emphasizes liver as the core，rather than just from the aspect of spleen and kidney. Dysfunction of “the metabolism adjusting system of the liver” is the vital pathological mechanism for glycolipid metabolism disese (GLMD). The therapies based on it are effective for metabolic disease. The results of modern biological researches indicate that liver influences the process of glucose and lipid metabolism through new metabolic hormones like FGF21 and Adiponectin. This article aims to discuss the material base of “liver as a core”. It is meaningful for figuring out the bio-essence of “the metabolism adjusting system of the liver” and vital Chinese Medicine pathological substance in GLMD.