To optimize the best formula of Shiwei Yipi Granules.Methods:The best formula of Shiwei Yipi granules was optimized by adding sweetener and flavors.The comprehensive evaluation of fuzzy mathematics was applied to different taste-modifying formula to determine the best formula.Results:The combination of aspartame and orange flavor had the best taste-modifying effect.Taste-modifying formula was as follows:10.0 g of aspartame and 5.0 g of orange flavor were added in 1 kg of Shiwei Yipi Granules.Conclusion:Fuzzy mathematics can be used in the selection of taste-modifying formula of Shiwei Yipi Granules.The taste-modifying formula got by this experiment can provide reference for the industrialized production of the preparation.