To screen the preparation technology and prescription of Runhou Qingyan orally disintegrating tablets,and to establish the method for determination of content of catechin and epicatechin in Runhou Qingyan orally disintegrating tablets.Methods:The Runhou Qingyan orally disintegrating tablets was prepared by powder direct compression method.The hardness,friability,mouthfeel and disintegration time were the main evaluation indexes for single-factor screening experiments of the disintegrants,lubricants and fillers.L9 (33) orthogonal experimental design was used for the optimization prescription,and high performance liquid chromatography (HPLC) was applied for the determination of Runhu Qingyan orally disintegrating tablets catechin,epicatechin content with the CAPCELL PAK C18 column,0.04 moL/L citrus citric acid solution-N,N-dimethylformamide-tetrahydrofuran (45:8:2) as the mobile phase at a detection wavelength of 280 m,a flow rate of 1.0 mL/min and a column temperature of 25 ℃.Results:The best prescription of Runhou Qingyan orally disintegrating tablets had good appearance and taste,which can be completely disintegrated in 60 s.The content of catechin had a good linear relationship in the range of 0.1486 mg-2.972 mg with r=0.9999 (n＝5),and the content of epicatechin had a good linear relationship in the range of 0.103 mg-2.06 mg,r=0.9998 (n＝5).The average recovery rates in the 2 groups were 98.49% and 98.56%,and RSDs of which were 1.33% and 1.87%.Conclusion:Optimized Runhou Qingyan orally disintegrating tablets prescription is rational,and the process is feasible.The disintegration is rapid,which has good taste and adjustable quality.