To observe Fuzheng Kangai Decoction on the anti-transfer mechanism of Lewis lung cancer in mice.Methods:A total of 50 C57BL/6 mice，half male and half female，were selected，and each mouse was inoculated with 0.2 mL of tumor cells under the armpit for 24 hours，and then were randomly divided into control group，DDP group，Fuzheng Kangai Decoction low，medium and high dose group，with 10 mice in each group.They were respectively administrated for 21 days，and the complete tumor tissue was taken out for weighing inhibitory rate calculation.The expression of Bcl-2 and Bax mRNA in Lewis lung cancer tissues were detected by Real-time fluorescent quantitative polymerase chain reaction (PCR) detection.The expression of MMP-9 protein in Lewis lung cancer tissues was detected by immunohistochemistry.And the expression of vascular endothelial growth factor (VEGF)，epidermal growth factor receptor (EGFR) in Lewis lung cancer tissues was detected by method of western blot (WB).Results:Compared with the model group，Fuzheng Kangai Decoction could inhibit the tumor growth of Lewis lung cancer-bearing mice in a dose-dependent manner，and significantly increase the expressions of Bax mRNA in Lewis lung cancer tissues，and decrease the expression of Bcl-2 mRNA and MMP-9 protein.There were significant differences compared with the model group (P<0.01).The expressions of VEGF，EGFR in Lewis lung cancer tissues was significantly increased in the model group，and Fuzheng Kangai Decoction could significantly reduce the expressions of VEGF，EGFR in Lewis lung cancer tissues.There was a significant difference compared with the model group (P<0.01，0.05).Conclusion:Fuzheng Kangai Decoction can inhibit lung cancer cell proliferation，inhibit the expression of Bcl-2 gene in lung cancer cells，activate the high expression of Bax and down-regulate the expression of VEGF，EGFR and MMP in lung cancer cells.