To evaluate the efficacy and safety of traditional Chinese medicine (TCM) combined with western medicine in the treatment of ventricular remodeling after acute myocardial infarction (AMI).Methods:The literatures of Chinese National Knowledge Infrastructure (CNKI), Wanfang Journal Database, PubMed, and Cochrane Library from date of their establishment to August 2018 were searched for the randomized controlled trials of compared TCM combined with western medicine and western medicine alone for ventricular remodeling after AMI.The quality of the literature included was evaluated according to the Cochrane, and the Revman 5.3 software was used to perform the Meta-analysis, and Grade Pro software to evaluate the evidence level of the main outcome indicators.Results:A total of 17 studies were included, accounted for a total of 1501 patients.Meta-analysis showed that combination therapy reduced left ventricular end-diastolic volume (SMD=-0.37［-0.63,-0.12］), decreased left ventricular mass index (SMD=-0.41［-0.76,-0.07］), increased left ventricular ejection fraction (SMD=0.79［0.58, 1.00］).Treatment efficiency was higher than conventional treatment (OR=4.56［2.27, 9.17］).Conclusion:TCM can safely and effectively reduce the degree of ventricular remodeling in patients after AMI.