To explore the effects of liver-regulating，kidney-tonifying and mass-eliminating therapy by stage on life quality，immune function and disease progression in patients with advanced breast cancer in stable period. Methods:A total of 100 patients admitted to Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine with advanced breast cancer who were in stable period after the first-line chemotherapy from September 2014 to September 2017 were randomly divided into treatment group (50 cases) and control group (50 cases). The control group was treated with routine therapy of Western medicine，on the basis of which the treatment group was combined with traditional Chinese medicine (TCM) therapy to regulate liver，tonify kidney and eliminate the mass by stage. Analysis and comparison of post-treatment Kanofsky score (KPS)，quality of life score (EORTC-QLQ-C30)，Hamilton Depression Scale score (HAMD)，TCM syndrome score，peripheral blood cell immunity，humoral immunity，progression-free survival (PFS)，and median progression-free survival (M-PFS) of two groups were made. Results:The improvement rate of KPS score in the treatment group was better than that in the control group (P<0.05). The physical，character，emotion function and overall quality of life scores were higher than those of the control group (P<0.05). The effective rate of HAMD score was significantly higher than that of the control group (P<0.05). In terms of TCM syndrome scores，the scores of the treatment group decreased significantly after treatment. The total syndrome scores，depression，insomnia，upset，irritability，spontaneous sweating，night sweating，dysphoria with feverish sensation in chest，palms and soles，soreness and weakness of waist and knees，limb numbness，and dry mouth symptoms scores were lower than those of the control group (P<0.05). After treatment，the levels of CD3+，CD4+，CD4+/CD8+，NK cells，immunoglobulin IgG，IgM，IgA were higher in the treatment group than those in the control group (P<0.05). After treatment，PFS and M-PFS in the treatment group were longer than those in the control group (P<0.05). Conclusion:TCM liver-regulating，kidney-tonifying and mass-eliminating therapy by stage can alleviate TCM syndromes and depression in patients with advanced breast cancer in stable period，improve quality of life，improve immune function，and delay disease progression.