To explore the clinical efficacy of Compound Radix Arnebiae Oil in the treatment of childhood eczema. Methods:A total of 80 pediatric eczema patients admitted to Yellow River Central Hospital from January 2015 to December 2017 were selected and divided into 2 groups according to the random number table，with 40 cases in each group. The control group was treated with skin lightening ointment and the research group was treated with Compound Radix Arnebiae Oil. The therapeutic effects，clinical symptoms and immune improvement of the 2 groups were analyzed. Results:The effective rate was 95.0% in the study group and 80.0% in the control group. The treatment effect of the study group was significantly better than that of the control group (P<0.05). The level of il-4 in the study group was significantly lower than that in the control group (P<0.05)，and the level of ifn-alpha in the study group was significantly higher than that in the control group (P<0.05). The CD8+ level of the study group was significantly lower than that of the control group (P<0.05)，and the CD4+ and CD4+/CD8+ levels of the study group were significantly higher than those of the control group (P<0.05). The improvement of symptom score of the study group was better than that of the control group (P<0.05)，and the hospitalization time of the study group was significantly less than that of the control group (P<0.05). Severe adverse reactions were found in both groups，and minor adverse reactions were relieved after adjustment of medication. There was no statistically significant difference in the occurrence of adverse reactions between the 2 groups (P<0.05). Conclusion:Compound Radix Arnebiae Oil is effective in treating infantile eczema and should be widely used in clinic.