To explore the curative effects of Yiqi Huoxue Jiedu Decoction combined with western medicine on patients with helicobacter pylori (Hp) positive chronic atrophic gastritis (CAG) and its effects on pepsinogen (PG). Methods:A total of 74 patients with Hp positive CAG treated in Zhengzhou Hospital of Traditional Chinese Medicine from November 2016 to February 2018 were selected and randomly divided into the control group and the observation group，with 37 patients in each group. The patients with Hp positive CAG in the control group were treated with quadruple therapy. The patients with Hp positive CAG in the observation group were treated with Yiqi Huoxue Jiedu Decoction on the basis of the same treatment in control group. After 3 months of treatment，the levels of PG (PGI，PGII，PGI/PGII)，inflammatory factors and blood rheological index were measured to evaluate the efficacy. Results:The total effective rate was 94.59% in the observation group and 72.97% in the control group (P<0.05). After treatment，the levels of pH，inflammatory factors (IL-6，TNF，CRP)，blood rheological index (whole blood viscosity high shear，whole blood viscosity low shear，plasma viscosity，erythrocyte aggregation index) decreased，and the levels of PGI，PGII，PGI/PGII increased in both groups (P<0.05)，and the levels of pH，inflammatory factors (IL-6，TNF，CRP)，blood rheological index (whole blood viscosity high shear，whole blood viscosity low shear，plasma viscosity，erythrocyte aggregation index) in the observation group were lower than those in the control group，the levels of PGI (PGI，PGII，PGI / PGII) were higher than the control group (P<0.05). Conclusion:Yiqi Huoxue Jiedu Decoction combined with western medicine quadruple therapy has bacteriostatic effects on Hp，and it can effectively control the levels of PG and inflammatory factors in Hp positive CAG patients，improve hemodynamics，protect gastric mucosa，which has a good therapeutic effect with high clinical value.