To observe the clinical efficacy of Xiaoxianxiong Decoction combined with Danshen Decoction in the treatment of viral myocarditis (VMC) with intermingled phlegm and heat and its effects on the level of inflammatory cytokines,immune function,oxygen free radicals.Methods:A total of 148 patients with VMC treated in First Affiliated Hospital of Henan university of Chinese Medicine from September 2015 to September 2017 were selected and divided into the control group and the observation group according to random number table method,with 74 cases in each group.The control group was given conventional medicine such as rehydration and myocardial nutrition.The observation group was given Xiaoxianxiong Decoction and Danshen Decoction on the basis of the same treatment in control group.The changes of clinical efficacy,endothelial function,oxygen free radicals,inflammation factors,immune function and the myocardial enzyme of the 2 groups were observed.Results:There was no statistically significant difference of IL-6,IL-2,TNF-α,INF-γ,NO,ET-1,SOD,MDA,CD4+,CD4+/CD8+,CD3+,CD8+,AST,LDH,CK,CK-MB of two groups before treatment (P>0.05).The levels of IL-6,IL-2,TNF-α,INF-γ,CD8+,AST,LDH,CK,CK-MB,ET-1,MDA of the 2 groups were decreased after treatment (P<0.05).The levels of NO,SOD,CD4+,CD4+/CD8+,CD3+ of the 2 groups were increased after treatment (P<0.05).The total effective rate of the observation group (91.89%) was significantly higher than the control group (78.38%).The difference between the two groups was statistically significant (P<0.05).Conclusion:The Xiaoxianxiong Decoction combined with Danshen Decoction can reduce the levels of the inflammatory cytokines,anti-oxidation,and improve the endothelial function,regulate the immune function to improve the clinical efficacy of in treating viral myocarditis.