To observe the curative effect of Buyuan Congnao decoction combined with acupuncture on senile patients with dementia (kidney deficiency and phlegm stasis pattern) and effect on MMSE, homocysteine (Hcy), amyloid beta-protein (Aβ) . Methods:Ninety-eight patients with dementia (kidney deficiency and phlegm stasis pattern) who were admitted and treated in Yanan university affiliated hospital from July 2014 to August 2016 were selected as the study objects, and were divided into observation group and control group, with 49 patients in each group according to random number table. The control group was treated with acupuncture, and the observation group was treated combined with Buyuan Congnao decoction on the basis of conventional treatment. Clinical effect, TCM symptom score, MMSE, Hcy and Aβ levels were observed in the two groups. Results:The total effective rate of the patients in the observation group was 87.76%, which was significantly higher than that of 69.39% of the control group (P<0.05). After treatment, scores of fatigue and lack of strength, mental decline, limb heaviness, verbal reversal, incontinence, dizziness and tinnitus were significantly lower than those before treatment (P<0.05), and those of the observation group were significantly lower than those of the control group (P<0.05). After treatment, scores of orientation, language ability, attention and calculation ability, memory were significantly higher than those before treatment (P<0.05), and those of the observation group were significantly higher than those of the control group (P<0.05). After treatment, Hcy and Aβ levels were significantly lower than those before treatment (P<0.05), and those of the observation group were significantly lower than those of the control group (P<0.05). Conclusion:Buyuan Congnao decoction combined with acupuncture can effectively improve Hcy and Aβ levels of senile patients with dementia (kidney deficiency and phlegm stasis pattern), and can improve cognitive function and clinical effect.