To observe the clinical effects of Shentong Zhuyu Decoction on osteonecrosis of the femoral head，and to explore the effects of hemorheological changes. Methods:A total of 60 patients with osteonecrosis of the femoral head admitted to Baoji Central Hospital were randomly divided into control group and observation group，with 30 cases in each group. The two groups were treated with conventional treatment of osteonecrosis of femoral head. The control group was treated with extracorporeal shock wave therapy in addition to basic plan，on the basis of which the observation group was given Shentong Zhuyu Decoction 1 doses/day，and 200 mL decoction in the morning and evening. The two groups were treated continuously for 8 weeks. The quality of life score (SF-36 quality of life scale)，hip joint Harris score，McMillan pain assessment table，bone density，osteocalcin and hemorheological indexes were compared before and after treatment in two groups. Results:The score of SF-36 quality of life in the two groups was increased (P<0.05)，and the increase of the observation group was better than that of the control group (P<0.05); the Harris score of the hip joint was increased after treatment (P<0.05)，and the observation group was superior to the control group (P<0.05); the FPS-R pain scores in the two groups were decreased than that before the treatment (P<0.05)，and the decrease in the observation group was more obvious (P<0.05); the bone mineral density and osteocalcin in the two groups were increased after the treatment (P<0.05)，and the observation group was better than the control group (P<0.05); after treatment，the whole blood low reduction viscosity (LRV)，the whole blood middle reduction viscosity (MRV)，and the whole blood high reduction viscosity (HRV)，plasma viscosity (PV) and fibrinogen (Fib) were decreased than those before treatment，and the decrease in the observation group was more obvious (P<0.05). Conclusion:Shentong Zhuyu Decoction has an ideal effect on osteonecrosis of the femoral head，and its mechanism may be related to the improvement of hemorheology.