To explore the effects of Shenyan Kangfu tablets combined with tripterygium polyglycoside tablets on the renal function and serum biochemical indicators of patients with mesangial proliferative glomerulonephritis.Methods:A total of 62 cases of patients with mesangial proliferative glomerulonephritis (MsPGN) in Beijing Wangfu Integrated Chinese and Western Medicine Hospital from January 2015 to Deceomber 2016 were selected and divided randomly into observation group and control group, with 31 cases in each group.The control group were treated with routine western medicine, and the observation group were treated with Shenyan Kangfu tablets combined with tripterygium polyglycoside tablets on the basis of the control group, the 2 groups were treated for a month continuously.The clinical efficacy traditional Chinese medicine score (TCM), and renal function indexes and serum biochemical indexes of 2 groups before and after treatment were compared.Results:After treatment, the total effective rates of observation group was 93.55%, which was obviously higher than that 74.19% in control group (P<0.05); Compared with before treatment, TCM scores of fatigue, dry mouth, night sweats, edema, proteinuria and hematuria, the levels of serum, serum creatinine (Scr), blood urea nitrogen (BUN), tumor necrosis factor-α (TNF-α), total cholesterol (TC), triacylglycerol (TG) and urinary albumin excretion rate (UAER) of 2 groups decreased obviously (P<0.05), and the observation group was obviously lower than the control group (P<0.05).The glomerular filtration rate (GFR) and serum albumin (ALB) of 2 groups increased obviously after treatment, and observation group was obviously higher than control group (P<0.05).Conclusion:Shenyan Kangfu tablets combined with tripterygium polyglycoside tablets in the treatment of MsPGN can improve the TCM scores and renal function, and improve the serum biochemical indicators that the clinical efficacy is outstanding.