To compare the differences of dermoscopic images of patients with androgenic alopecia in different traditional Chinese medicine (TCM) syndromes,and to explore the application value of dermatoscope in the skin syndrome differentiation of androgenetic alopecia.Methods:A total of 120 patients with androgenetic alopecia were divided into three groups,with 40 cases in each group.The three were liver and kidney deficiency group,blood heat group and dampness-heat of spleen and stomach group.Images were taken by dermatoscope with polarized light,and there were three images for every patient.Peripilar signs (PPS),yellow dots,blood vessels,and honeycomb signs were chosen as index to observe the differences in the three types of syndromes.Results:In the unit dermatoscope field of view,the results were shown as follows.Firstly,the rate of yellow dots positive was that index in dampness-heat of spleen and stomach group was higher than index in blood heat group (P<0.01) and kidney deficiency group (P<0.01).Secondly,the rate of blood vessels signs positive was that index in blood heat group was higher than index in liver and kidney deficiency group (P<0.01) and dampness-heat of spleen and stomach group (P<0.01),and spleen and stomach group was higher than liver and kidney deficiency group (P<0.05).Thirdly,the rate of honeycomb signs was that index in liver and kidney deficiency group was higher than index in blood heat group (P<0.01) and dampness-heat of spleen and stomach group (P<0.01).Fourthly,the number of Peripilar signs was that index in liver and kidney deficiency group was higher than index in blood heat group (P<0.01) and dampness-heat of spleen and stomach group (P<0.01).Fifthly,the correlation analysis was that overall statistics of all patients showed positive correlation between the number of Peripilar signs and the course of disease (r=0.369,P<0.01).Grouping statistics showed that there was positive correlation between the number of Peripilar signs and the course of disease in dampness-heat of spleen and stomach group and liver and kidney deficiency group (r= 0.410,P<0.01; r=0.549,P<0.01).Conclusion:Different syndromes of androgen alopecia patient's dermoscopic images show certain differences between positive rate and quantity of dermoscopic signs.Dermatoscope could be used in the treatment of TCM syndrome differentiation of androgenic alopecia.