Asthma is a heterogeneous disease characterized by airway hyperreaction and chronic airway inflammation, which can eventually lead to airway remodeling and other irreversible organic damage.The pathogenesis of asthma is complex, involving a variety of inflammatory cells, cytokines, chemokines and inflammatory mediators, and is regulated by environmental factors and epigenetic factors.With the development of molecular biology and genetics in recent years, Dendritic cells (DC) are considered to be a biological system composed of a variety of phenotypic and functional subsets.It is an important cell involved in the pathogenesis of asthma, and plays a key role in initiating immune response and maintaining immune tolerance in asthma.Different phenotypes of DC have different functions such as uptake, processing and presentation antigens, activation of initial T lymphocytes, mediating immune response and immune tolerance, which directly affect the development of asthma.Glucocorticoids are still proven to be the most effective drugs for preventing asthma attacks, but their side effects attract much attention.Instead, more and more experts and scholars have paid more attention to the mechanism of multi target treatment of asthma by traditional Chinese medicine.DC is undoubtedly an important target for exploring the pathogenesis of asthma and exploring the safe and effective immunotherapy and the development of natural Chinese medicine products.In the paper, the general situation of DC, the understanding and correlation between DC and the pathogenesis of asthma between traditional Chinese medicine and Western medicine and the main research work are stated in order to provide some ideas for future interpretation of traditional Chinese medicine in the prevention and treatment of asthma mechanism and the research and development of new drugs.