Kangfuxin Decoction is the ethanolic extract of Periplaneta Americana (L.), whose main effect is promoting blood circulation, nourishing yin and promoting granulation, thus having the effects of promoting wound healing, anti-inflammatory, detumescence, analgesia, regulating immunity, antibacterial, antitumor and antioxidant, etc.Besides, it has no obvious adverse reactions.Therefore, Kangfuxin Decoction is widely used in the prevention and treatment of oral diseases.This paper reviewed the clinical curative effects of Kangfuxin Decoction in treatment of oral disease in the last 5 years, and analyzed the material basis and mechanism, so as to provide references for expanding the clinical application, intensively studying material basis of the efficacy and pharmacological mechanism of Kangfuxin Decoction.