To establish the fingerprints of water extracts from different processed products (raw,salt and charcoal) of Eucommiae Cortex to characterize the changes of chemical components before and after processing at the overall level,and to provide reference for the quality control of Eucommiae Cortex.Methods:HPLC method was applied,and Kromasil 100-5-C18 column was used with 0.3% phosphoric acid in water (v/v)-acetonitrile as the elution system in gradient elution mode.The flow rate was 1.0 mL/min and the detective wavelength was 238 nm.Fingerprint Similarity Evaluation System (2012 A edition) was used to establish fingerprints of 10 batches of different processed Eucommiae Cortex products.Meanwhile,Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA) as methods of pattern recognition were applied to give an overall evaluation.Results:The common modes of HPLC fingerprint for different processed Eucommiae Cortex were set up.There were 7 common peaks in crude and salt products,respectively,and 8 common peaks for the charcoal products.Conclusion:The combination of fingerprints and chemical pattern recognition was an effective method for the distinction between different processed Eucommiae Cortex.The results would provide meaning references for quality evaluation of Eucommiae Cortex.