To improve the quality standard of Qingre Jiedu Oral Solution.Methods:TLC (Thin-Layer Chromatography) methods were used for the qualitative identification of Forsythiae Fructus，Cortex Phellodendri，Fructus Gardeniae and Radix Paeoniae Rubra，and HPLC (High Performance Liquid Chromatography) method was used to determine chlorogenic acids of the main drug Flos Lonicerae.Results:Identification method of the TLC about Forsythiae Fructus，Cortex Phellodendri，Fructus Gardeniae and Radix Paeoniae Rubra etc in Oral Solution was established.Under the selected conditions of HPLC，an identification method for chlorogenic acids in Oral Solution was established and the methodology complies with the requirements of Chinese Pharmacopeia.Conclusion:The identification and quantitative determination method is simple，accurate and reproducible，which can be applied to the quality control of Qingre Jiedu Oral Solution.