To explore the diagnosis and treatment of acupoint blood-letting therapy for chronic urticaria.Methods:We electronically searched literatures related to acupoint blood-letting therapy for chronic urticaria in the following databases：CNKI (1979-2017)，VIP (1989-2017)，CBM (1979-2017)，PUBMED (1966-2017).Then the clinical characteristics of syndrome differentiation，intervene measures related to acupoint blood-letting therapy，acupuncture points selection method，treatment effect，safety in treating chronic urticaria by acupoint blood-letting therapy，etc.were summarized and analyzed.Results:In the collected 41 articles，blood-letting points selection method by differentiation of disease was 33 (33/41，80.5 %) articles.Triangle-edged needle was involved in 31 (31/41,75.6%) articles and cupping therapy was referred in 24 (24/41,58.5%） articles.The main acupuncture points chosen in the 41 articles in the frequency order were GV14 (Dazhui)，BL13 (Feishu)，SP10 (Xuehai)，LI11 (Quchi)，BL17 (Geshu).The effective rate varied from 63.33% to 100% when blood-letting therapy was conducted alone while the effective rate varied from 80.0% to 100%.Blisters appeared after cupping was reported in 1 study.Conclusion:Acupoint blood-letting points selection method by differentiation of disease was the main method in the treatment of aucpoint blood-letting therapy for chronic urticaria.Triangle-edged needle and cupping is widely used for blood-letting.The main acupuncture points applied in acupoint blood-letting therapy for chronic urticaria were GV14，BL13，SP10，LI11，BL17.The short-term efficacy of acupoint bloodletting therapy for chronic urticaria was effective.But the long-term efficacy and its safety need further evaluation.