To provide the theoretical basis for the research，compatibility and clinical application of Vitex agnus-castus L.in China based on the scientific literature of Vitex agnus-castus L.and traditional Chinese medicine theory to explore the medicinal properties of it.Methods:After checking the related documents in CNKI，Web of science and Pubmed databases，the irrelevant and duplicate documents，accept documents which has rational design，high reliability，and reliable conclusions were selected out.The medicinal properties of Vitex agnus-castus L were studied combining its' clinical trials，chemical constituents researches，pharmacological researches and traditional Chinese medicine theory.Results:The preliminary inference of the traditional Chinese medicinal properties of Vitex agnus-castus L.were as follows：the property and flavor were pungent，sweet，slightly cold and belonging to liver and kidney; the function was soothing the liver to remove stagnancy of liver-qi，filling essence，strong sinews and bones.It could be used for the treatment of premenstrual syndrome irritability，emotional restlessness，breast tenderness，headache，etc.，and to prevent osteoporosis and promote fracture healing.Conclusion:Summarizing the characteristics of natures，tastes，guiding，function indications，usage and dosage，it will lay a theoretical foundation for the compatibility and clinical application of Vitex agnus-castus L..