To explore the effects of Traditional Chinese Medicine (TCM) with syndrome differentiation in the treatment of chronic heart failure，and its influences on serum brain natriuretic peptide and serum uric acid，and to provide reference for the clinical treatment of chronic heart failure. Methods:A total of sixty patients with chronic heart failure who were admitted to Chuiyangliu Hospital from January 2017 to June 2018 were selected and randomly divided into observation group and control group，with 30 cases in each group. Patients in the control group were treated with conventional Western medicine，and patients in the observation group were given TCM treatment based on the above treatments. The levels of serum brain natriuretic peptide (BNP)，serum uric acid (UA)，and changes in cardiac function before and after treatment were compared between the two groups of patients. The curative effect of heart failure after treatment and the effect of TCM symptom were analyzed. Results:There was no significant difference in the level of serum cardiac function and serum BNP and UA before treatment between the two groups (P>0.05). After treatment，CI and LVEF in the two groups were significantly increased，serum BNP，UA levels，and LVDD were significantly reduced，and the above indicators improved more in the observation group (P<0.05). After treatment，the efficacy of TCM syndrome and heart failure in the observation group were significantly better than those in the control group. The difference was statistically significant (P<0.05). Conclusion:TCM syndrome differentiation treatment for patients with chronic heart failure can significantly reduce serum BNP and UA levels，improve cardiac function，better promote TCM symptom and heart failure recovery，and reduce patients' suffering，and the effect is significant.