To investigate the effects of puerarin combined with conventional anti-osteoporosis therapy on bone density after artificial hip arthroplasty in elderly patients.Methods:A total of 58 elderly women who were treated with artificial hip arthroplasty in The People's of Hospital Kaizhou District from May 2015 to May 2016 were selected and divided into experiment group (n＝29) and control group (n＝29) according to computer generated random digital table.The 2 groups were treated with artificial hip arthroplasty.14 days after the treatment，the control group was given oral calcium Erqi D tablets，ossification triol capsules and intravenous infusion of zoledronic acid，and the experiment group was given intravenous infusion of puerarin injection based on the control group.The 2 groups were treated continuously for 2 months，and the patients were followed up for 6 months.The clinical therapeutic effects and incidence of adverse reactions were collected，and the hip function was assessed by Harris scoring system and the bone density around the prosthesis was measured.Results:The effective rate was 86.21% in the experiment group and 79.31% in the control group，it had no statically difference between the 2 groups (P>0.05).The Harris score and hip function was gradually increasing from 7 days to 6 months after operation，and the experiment group were higher than the control group 3 and 6 months after surgery (P<0.05 or P<0.01).Compared with 3 months after operation，there was no significant changes in bone density in the experiment group at 6 months after operation，R4-R7 of the bone density in the control group decreased，R6 and R7 of the bone density in the experiment group was significantly higher than those in the control group at 6 months after operation (P<0.05 or P<0.01).During the treatment，the 2 groups had varying degrees of fever，myalgia，flu-like symptoms，joint pain and headache，and the incidence of adverse reactions in the 2 groups had no significant difference (P>0.05).Conclusion:The clinical efficacy of puerarin combined with conventional anti-osteoporosis treatment after artificial hip arthroplasty therapy in elderly female patients with senile osteoporosis is significant，and the hip function and the bone density around the prosthesis are effectively improved and the safety is good.