To analyze the clinical effects of Dangbanxia Xiexin Decoction on chronic atrophic gastritis (CAG) of damp-heat-type spleen and stomach，and its influence on serum inflammatory index and immune function，so as to explore the mechanism of curative effect，so as to provide a reference for the selection of treatment scheme for CAG patients with damp-heat-type spleen and stomach. Methods:A total of 120 cases of spleen-stomach damp-heat CAG were selected，which were admitted to Jingzhou Hospital of Traditional Chinese Medicine from January 2015 to January 2017. The patients were numbered according to the order of admission. Odd number patients were selected into control group，and even number patients were selected into observation group，with 60 cases in each group. These 2 groups of patients were given daily life guidance and “lansoprazole tablets + Amoxicillin Capsules + clarithromycin capsules” treatment，the observation group was given Add or Subtract Banxia Xiexin Decoction treatment on the basis of control group. 2 groups of patients were treated for 2 months. The scores of Traditional Chinese Medicine (TCM) symptoms，immune function indexes (CD3+，CD4+，CD8+，CD4+/CD8+)，serum inflammatory indexes (IL-2，IL-6，TNF-α，G-17) were compared between the 2 groups before and after treatment. Evaluation of TCM syndrome treatment，curative effect，disease curative effect. The adverse drug reactions / side effects of the 2 groups were compared during the treatment period. Results:1) After 2 months of treatment，the scores of gastric epigastric or elbow costal distention，gastric burning，dry mouth，nausea and vomiting in the 2 groups were significantly lower than those before treatment，and the observation group was significantly lower than the control group. The total effective rate of syndrome in the observation group was significantly higher than that in the control group (P<0.05). 2) The levels of serum inflammatory factors IL-2，IL-6 and TNF-α were significantly lower in the observation group than those in the control group，and G-17 was significantly higher in the observation group than in the control group (P<0.05). 3) After treatment，CD3+，CD4+，CD4+/CD8+ of the 2 groups were significantly higher than before treatment，and the observation group was higher than the control group (P>0.05)，CD8+ were significantly lower than before treatment，and the observation group was lower than the control group (P<0.05). 4) After treatment，the total effective rate of TCM syndrome in the observation group was significantly higher than that in the control group (P<0.05). In the observation group，the total effective rate of spleen-stomach damp-heat CAG was significantly higher than that of the control group (P Conclusion:Banxia Xiexin Decoction can improve the gastric inflammation and immune function of patients with spleen-stomach damp-heat CAG，improve the clinical symptoms，enhance the clinical therapeutic effect，and do not increase the toxic and side effects of drugs，so it has high clinical value.