To analyze the clinical efficacy of Jianpi Shengxue Tablet in the treatment of hypersplenism due to cirrhosis.Methods:From January 2013 to October 2016，a total of 160 patients with liver cirrhosis and hypersplenism admitted to the outpatient department and ward of Hepatology Department of the Third People's Hospital of Hubei Province were randomly divided into control group and observation group.The control group was treated with routine liver protection and anti-fibrosis，and the observation group was treated with Jianpi Shengxue Tablets on the basis of routine treatment for 8 weeks.The clinical symptoms and signs like epistaxis or odontorrhagia，asthenia，anorexia，abdominal distension，stool condition，spider mite，white blood cell (WBC)，platelet (PLT)，red blood cell (RBC)，serum alanine aminotransferase (ALT)，serum total bilirubin (TBiL)，albumin (ALB)，prothrombin time (PT)，liver real-time elastography liver fibrosis index (LFI)，indocyanine green (ICG) test，Child-Pugh liver function classification，changes of spleen color ultrasound before and after treatment were observed in the two groups.The blood routine of the observation group before and after treatment with different TCM syndrome types were further compared and analyzed.Results:WBC，PLT，RBC count in the observation group before and after treatment and after treatment in both groups had statistical significance (P<0.05).There was no significant difference in ALT and TBiL between the two groups after treatment (P>0.05)，and there was a significant difference in ALB and PT between the two groups after treatment (P<0.05).There were significant differences in LFI，ICG15，and Child-Pugh classification scores between the two groups after treatment (P<0.05).There was no significant difference in the inner diameter of portal vein and length of spleen between the two groups after treatment (P>0.05)，and there was significant difference in the thickness of spleen between the two groups after treatment (P<0.05).There was no significant difference in WBC，PLT and RBC between the two groups before and after treatment (P>0.05)，but there was significant difference in other five types (P<0.05)，especially in spleen and kidney yang deficiency，internal resistance of dampness and blood stasis.Conclusion:Jianpi Shengxue Tablets can obviously improve the symptoms of fatigue，anorexia，abdominal distension，epistaxis or odontorrhagia in patients with cirrhosis and hypersplenism，and improve the liver anabolic function，especially applicable to the patients with spleen and kidney yang deficiency，dampness and internal resistance，blood stasis type cirrhosis，which is worthy of clinical application.