To evaluate gastrointestinal reactions and changes of life quality in the aged patients with acute myeloid leukemia (AML) (M3 excluded) undergoing induction chemotherapy combined with Kanglaite Injection.Methods:A retrospective clinical study was performed.A total of 140 aged patients with AML admitted to Dongzhimen Hospital from January 2009 to January 2016 were screened and divided into two groups：those who received Kanglaite Injections were categorized into the combined treatment group，while those who did not were placed in the simple treatment group.Results:A total of 55 aged patients with AML (M3 excluded) were eligible for inclusion according to clinical study criteria，among which 23 were placed in the simple treatment group，and 32 were placed in the Kanglaite Injection (combined treatment) group.In the combined treatment group，10 were diagnosed as AML for the first time，while 22 were relapsed cases; in the simple treatment group，8 were diagnosed as AML for the first time，while 15 were relapsed cases.The differences in distribution were not statistically significant (P>0.05).Occurrence of grade I oral reaction，grade II oral reaction，and oral adverse reaction was 21.7%，17.4%，and 39.1% respectively in the simple treatment group，which was significantly higher than 0%，3.1%，and 3.1% in the combined treatment group (P=0.001<0.01).In regards to gastrointestinal reactions，occurrence of grade II reaction，grade III reaction，and adverse reaction was 30.5%，13.0%，and 43.5% respectively in the simple treatment group，which was higher than 12.5%，9.4%，and 34.4% in the combined treatment group，but the results were not statistically significant (P>0.05).After one course of induction chemotherapy combined with Kanglaite Injection for elderly AML (M3 excluded) patients，the KPS scores of improving，stabilizing and effective rates were 12.5%，75.0% and 87.5% respectively in the simple treatment group，and were 0%，65.2% and 65.2% respectively in the combined treatment group.Induction chemotherapy combined with Kanglaite Injection was significantly effective in improving quality of life (P<0.05).Conclusion:The results of this study indicate that induction chemotherapy combined with Kanglaite Injection has the following effects for elderly AML (M3 excluded) patients：improving oral toxic reactions and degrees，reducing gastrointestinal reactions，especially for relapsed patients，and improving life quality after 1 course of induced chemotherapy.