To explore the effects of Qianggu Capsule combined with sulfasalazine on bone metabolism in patients with rheumatoid arthritis complicated with osteoporosis. Methods:A total of 96 patients with rheumatoid arthritis complicated with osteoporosis in The Fifth Affiliated Hospital of Zhengzhou University were selected as study objects from January 2015 to January 2018，and they were randomly divided into control group and observation group with 48 cases in each group. All patients were treated with routine therapy，the control group was treated with sulfasalazine on the basis of routine therapy，and the observation group was treated with Qianggu Capsule on the basis of the control group，3 months as a course of treatment，the 2 groups were treated continuously for 2 courses. The clinical effects of the 2 groups were compared; the clinical symptoms of the 2 groups were evaluated before and after treatment; The bone metabolism levels of the 2 groups were detected and compared before and after treatment. Results:After treatment，the total effective rates of the observation group and the control group were 62.50% and 52.08% respectively. There was no significant difference in the total effective rate between the 2 groups. (P>0.05). After treatment，the joint tenderness index，joint function index and joint swelling index of the 2 groups were lower than those before treatment，and the morning stiffness time of the 2 groups was significantly shorter than that before treatment，and there were significant differences between the 2 groups (P<0.01). After treatment，the serum calcium concentration，BGP and PTH levels of the 2 groups were significantly higher than those before treatment (P<0.01)，the levels of ESR，BALP and CTX-I in the 2 groups were significantly lower than those before treatment (P<0.01)，and there were significant differences between the 2 groups (P<0.05 or P<0.01). After treatment，the BMD levels in the lumbar spine and Ward's Triangle were significantly higher of the 2 groups (P<0.01)，and the BMD levels in the observation group were significantly higher than those in the control group (P<0.01). Conclusion:Qianggu Capsule combined with sulfasalopyridine in the treatment of rheumatoid arthritis complicated with osteoporosis can effectively relieve the clinical symptoms，improve bone metabolism，increase BMD. It's beneficial to patients' rehabilitation.