基于基础疗法的芪苈强心胶囊综合用药对慢性充血性心力衰竭患者HR、LVEF、LVEDD水平的影响

doi:10.3969/j.issn.1673-7202.2019.02.039

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基于基础疗法的芪苈强心胶囊综合用药对慢性充血性心力衰竭患者HR、LVEF、LVEDD水平的影响
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                        10.3969/j.issn.1673-7202.2019.02.039
                    
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基金项目:上海市科委中药现代化专项(09DZ1970300)——慢性心力衰竭的中医药规范化诊疗

Effects of Qili Qiangxin Capsule Based on Basic Therapy on HR，LVEF and LVEDD Levels in Patients with Chronic Congestive Heart Failure

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目的：研究基于基础疗法的芪苈强心胶囊综合用药对慢性充血性心力衰竭患者心率（HR）、左室射血分数（LVEF）、左室舒张末期内径（LVEDD）水平的影响。方法：选取2016年1月至2018年1月山东省滨州市人民医院收治的慢性充血性心力衰竭患者94例，按照随机数字表法平均分为对照组和观察组，每组47例。对照组予以常规治疗，观察组则在常规治疗的基础上予以芪苈强心胶囊治疗。分别比较2组临床疗效，治疗前后HR、LVEF、LVEDD水平，治疗前后VEGF、NO水平以及血浆AngⅡ、ET、BNP水平。结果：观察组总有效率为91.49%（43/47），高于对照组的72.34%（34/47），差异有统计学意义（P<0.05）。治疗后观察组HR、LVEDD水平分别为（76.43±6.52）次/min、（46.12±4.08）mm，低于对照组的（88.61±7.33）次/min、（50.13±4.33）mm，而LVEF水平为（42.30±7.01）%，高于对照组的（36.72±6.11）%，差异均有统计学意义（均P<0.05）。治疗后观察组VEGF、NO水平分别为（522.58±127.57）ng/L、（43.49±7.01）μmol/L，高于对照组的（441.38±113.52）ng/L、（34.85±6.88）μmol/L，差异均有统计学意义（均P<0.05）。治疗后观察组血浆AngⅡ、ET、BNP水平分别为（135.42±24.48）pg/mL、（53.68±22.82）ng/L、（287.96±62.02）μg/L，低于对照组的（161.33±23.66）pg/mL、（84.68±27.48）ng/L、（372.02±64.86）μg/L，差异均有统计学意义（均P<0.05）。结论：基于基础疗法的芪苈强心胶囊综合用药治疗慢性充血性心力衰竭疗效明显，有利于促进患者心功能恢复，同时有效改善血管内皮功能。

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To study the effects of Qili Qiangxin Capsule based on basic therapy on HR，LVEF and LVEDD levels in patients with chronic congestive heart failure. Methods:A total of 94 patients with chronic congestive heart failure admitted to Binzhou People's Hospital of Shandong Province from January 2016 to January 2018 were studied. All patients were divided into observation group and control group by random number table method. The control group was treated with routine treatment，and the observation group was treated with Qili Qiangxin Capsule on the basis of routine treatment. Respectively，2 groups of clinical curative effect，HR，LVEF and LVEDD level before and after the treatment，VEGF and NO level before and after treatment and plasma Ang Ⅱ，ET，the BNP level were compared. Results:The total effective rate of the observation group was 91.49% (43/47)，which was higher than 72.34% (34/47) of the control group，and the difference was statistically significant (P<0.05). The observation group of HR，LVEDD after treatment was (76.43±6.52) times/min，(46.12±4.08) mm，which was lower than the control group of (88.61±7.33) times/min，(50.13±4.33) mm，and LVEF level was (42.30±7.01) %，which was higher than the control group (36.72±6.11) %，the difference was statistically significant (all P<0.05). After treatment，VEGF and NO levels in the observation group were (522.58±127.57) ng/L，(43.49±7.01) μmol/L，which was higher than the control group of (441.38±113.52) ng/L and (34.85±6.88)μmol/L，the difference was statistically significant (all P<0.05).The observation group after treatment of plasma Ang Ⅱ，ET，BNP levels were (135.42±24.48) pg/mL，(53.68±22.82) ng/L，(287.96±62.02) μg/L，which was lower than the control group of (161.33±23.66) pg/mL，(84.68±27.48) ng/L，(372.02±64.86) μg/L，the difference was statistically significant (all P<0.05). Conclusion:Qili Qiangxin Capsule based on basic therapy has obvious curative effect in the treatment of chronic congestive heart failure，which is conducive to the recovery of patients' heart function and the effective improvement of vascular endothelial function.

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刘永选,王彩虹.基于基础疗法的芪苈强心胶囊综合用药对慢性充血性心力衰竭患者HR、LVEF、LVEDD水平的影响[J].世界中医药,2019,(02).

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收稿日期:2018-09-06
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在线发布日期: 2019-03-04
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