To use Simiao Yongan Decoction to treat arteriosclerosis obliterans with heat-toxin amassment syndrome,and to observe the clinical efficacy to compare the changes of related indexes before and after treatment for analysis of its action mechanism.Methods:A total of 120 arteriosclerosis obliterans patients with heat-toxin amassment syndrome treated in First People's Hospital of Shangqiu City from January 2015 to December 2017 were selected and divided into the observation group and the control group,with 60 cases in each group.The two groups were treated with conventional western medicine therapy and clean dressing,and the control group was given fasudil hydrochloride injection intravenous infusion therapy,while the observation group was treated with Simiao Yongan Decoction based on the same treatment of the control group.Before treatment and 4 weeks after treatment,the clinical symptoms,inflammatory markers and hemorheology of the 2 groups were compared and evaluated,and the results were statistically analyzed.Results:After 4 weeks of treatment,the TNF-α,IL-18,whole blood viscosity,plasma viscosity,Fib levels of the 2 groups were significantly decreased compared with before the treatment (P<0.05),and the observation group improved more than those in the control group (P<0.05).The ABI and TBI measured by ultrasound method were significantly increased (P<0.05),which were increased more obviously than those of the control group (P<0.05).The comparison of 2 groups showed that the clinical symptoms such as the ulcer dimension,ulcer depth,granulation,inflammatory swelling,pain and ulcer score were significantly decreased (P<0.05),and the observation group improved more than those in the control group (P<0.05).Conclusion:Simiao Yongan Decoction can have effective clinical effects in the treatment of arteriosclerosis obliterans,which may be related to improving hemorrheology and eliminating inflammatory factors.