To investigate the effects of Compound Gegen Qinlian Decoction combined with N-acetylcysteine Capsules in the treatment of pulmonary fibrosis.Methods:A retrospective study method was used.From August 2014 to February 2016，96 patients with pulmonary fibrosis diagnosed and treated in Dongfeng Hospital Affiliated to Hubei University of Medicine were divided into observation group and control group according to the random number table method，with 48 patients in each group.The control group was given the N-acetylcysteine Capsules treatment，while the observation group was given Compound Gegen Qinlian Decoction combined with N-acetylcysteine capsules treatment，and two groups were observed for 3 months.Results:The effective rates of the observation group and the control group were 97.9% and 83.3% respectively.And the effective rate of the observation group was significantly higher than that of the control group (P<0.05).There were no significant differences of CT ground glass opacity，interlobular septal thickening image，reticular and honeycombing of positive numbers compared between the observation group and the control group before treatment (P>0.05)，and those of the observation group were significantly lower than that of the control group after treatment (P<0.05).The VC and TLC values in the observation group and control group after treatment were significantly increased than before treatment (P<0.05)，while those of the observation group after the treatment were also significantly higher than those of the control group (P<0.05).Conclusion:Compound Gegen Qinlian Decoction combined with N-acetylcysteine Capsules in treatment of pulmonary fibrosis can improve the curative effect，improve pulmonary fibrosis CT imaging features，promote the pulmonary function of patients，which is worthy of application.