To study curative effects of Xiao'er Feike Granules combined with Yitanjing (ambroxol hydrochloride and clenbuterol hydrochloride oral solution) on children with bronchial pneumonia and its effects on pulmonary function and inflammatory mediators.Methods:A total of 98 children with bronchial pneumonia admitted to Guangdong Maternity and Child Health Care Hospital from January 2017 to December 2017 were selected and divided into observation group (49 cases) and control group (49 cases) according to random table method.The control group was given Yitanjing，on the basis of which the observation group was given Xiao'er Feike Granules.The two groups were treated for 10 days.The curative effects of the two groups was compared including the main symptom score，the change of the lung function and the inflammatory mediators before and after the treatment，and the occurrence of adverse reactions were compared.Results:The total effective rate in the observation group (93.88%) was higher than that of the control group (73.47%) (P<0.05).Symptom scores including cough，wheezing，and expectoration decreased in two groups after treatment (observation group：t=22.626，25.554，29.063，control group：t=13.481，15.814，21.600，P<0.05); the symptom scores of the observation group after treatment of cough，wheezing and expectoration were lower than those of control group (t=18.087，17.850，22.170，P<0.05).After treatment，FEV1，FVC and PEF increased in two groups (observation group：t=21.507，20.238，21.206，control group：t=10.501，10.470，13.359，P<0.05); after treatment，FEV1，FVC and PEF in observation group were higher than those in control group (t=11.533，9.134，8.544，P<0.05).Serum IL-4，CRP and IL-18 levels decreased in two groups after treatment (observation group：t=21.658，22.520，18.904，control group：t=12.283，10.513，8.987，P<0.05); and the levels of serum IL-4，CRP and IL-18 levels after treatment in the observation group were lower than those in the control group (t=12.988，13.203，14.793，P<0.05).The incidence of adverse reaction in the observation group (8.16%) was lower than that of the control group (28.57%) (P<0.05).Conclusion:Xiao'er Feike Granules combined with Yitanjing has good curative effects in the treatment of children with bronchial pneumonia，and it can significantly improve lung function and reduce inflammation and adverse reaction，which is worthy of researching.