Metabolomics is a kind of newly emerged systematic biology research method，with integrity and dynamic nature. It can reflect the changes of metabolins when stimulating the living organism. Due to its accordance with the holism in traditional Chinese medicine(TCM)，it is widely used in TCM and Chinese materia medica. In the research of acupuncture mechanism，metabonomics has been taken as an effective method of research for a long time. There are more researches of metabonomics on acupuncture and moxibustion in recent years with certain achievements in terms of revealing the mechanisms of acupuncture and moxibustion. This paper made a review on current studies，wishing to provide new ideas for metabonomics being widely used in modern acupuncture research.