To observe the effects of cake-separated moxibustion on intercellular adhesion molecule-1(ICAM-1)and p-p38MAPK in rats with chronic bronchitis. Methods:A total of 48 Sprague-Dawley(SD)rats were randomly separated into the blank group，model group，cake-separated moxibustion group and paper pad-separated moxibustion team(12 in each group). In addition to the blank group，other 3 groups used modified fumigation to establish the chronic bronchitis models of rats. After intervention，the content of neutrophils in Bronchoalveolar Lavage Fluid(BALF)was measured. ICAM-1 mRNA was detected by RT-PCR，while protein contents of ICAM-1 and p-p38MAPK were detected by Western blot. Results:Compared with the blank group，the contents of neutrophils，p-p38MAPK and ICAM-1 mRNA were obviously increased in the model group(P<0.01). Compared with the model group，the number of neutrophils was decreased(P<0.05)and the contents of p-p38MAPK，ICAM-1 mRNA were significantly decreased(P<0.01). Compared with the paper pad-separated moxibustion group，the contents of neutrophils，p-p38MAPK，ICAM-1 mRNA and protein were significantly decreased in the cake-separated moxibustion group(P<0.05). Conclusion:Cake-separated moxibustion can inhibit the release of neutrophils and significantly reduce the inflammatory reaction，by reducing the contents of p-p38MAPK，ICAM-1 mRNA and protein，so as to treat chronic bronchitis.