Dioscorea nipponica is the main source of diosgenin and the main raw material for the production of contraceptives and steroid hormones compounds.The wild resources of D.nipponica has been unable to meet the increasing market demand,but artificial cultivation process does not regulate the use of pesticides,pesticide residues and heavy metals exceeding and other issues limit of sustainable development of the D.nipponicae rhizome industry.Pollution-free cultivation is an effective measure for high quality,high and stable yield of D.nipponicae rhizome and the main development direction in the future.This paper discusses the technical requirements of pollution-free cultivation of in precision origin location selection,improved variety cultivation,standardized comprehensive agronomic management measures,etc.Pest control should give priority to agronomic control and biological control,the use of chemical control with low toxicity and low residue in small amount is inevitable,and the use of chemical pesticides with high toxicity and high residue is prohibited.Through the construction of pollution-free cultivation technology system of D.nipponica,the standardization and industrialization of D.nipponicae rhizome production can be realized,meanwhile,the healthy development of D.nipponica planting industry will be promoted.