To rapidly establish the detection method for cimifugin and the amounts of four chromones in Saposhnikoviae Radix by near infrared spectroscopy. Methods:The contents of four chromones of 55 batches of Saposhnikoviae Radix was determined by high performance liquid chromatography as reference value. Combined with partial least squares regression(PLS)，the regression model was established. Different spectral pretreatment methods，wave ranges and optimal factors were selected. The stability of the models were evaluated by R2，RMSEP and RMSEC. Results:The optimum RMSEP values，RMSEC values and R2 values of cimifugin were 0.025 0，0.024 0 and 0.949 9，respectively. The optimum RMSEP values，RMSEC values and R2 values of the amounts of four chromones were 0.2460，0.1720 and 0.9110，respectively. Conclusion:The NIR quantitative models established in this study are accurate and can be used for rapid detection of quality of Saposhnikoviae Radix.