The study of meridian tropism has great significance to the development of Chinese herbal medicine theory. In recent years network pharmacology had been widely used in the study of traditional Chinese medicine(TCM). This study aims to explore the relationship between liver meridian and treatment based on network pharmacology for the possibility of meridian tropism theory adopting network pharmacology. Methods:Molecular docking was used to screen the active targets of Chinese medicine of liver meridian in Pharmacopoeia of the People's Republic of China(2015). Common active targets were searched between Chinese medicine of liver meridian and diseases. The frequency of Chinese medicine and protein with liver meridian in different disease would be analyzed to explore the relationship between tropism and indication. Results:The albumen targets of Chinese medicine of liver meridian has a high frequency in the diseases of mental and behavioural disorders，diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism，pregnancy，childbirth and the puerperium. Conclusion:The relationship between treatment and Chinese medicine of liver tropism based on network pharmacology is related to physiological function of liver.